Trimeprazine

Names

[ CAS No. ]:
84-96-8

[ Name ]:
Trimeprazine

[Synonym ]:
Methylpromazine
Isobutrazine
EINECS 201-577-3
Repetin
Alimemazine
N,N-dimethyl-N-<2-methyl-3-(10H-10-phenothiazinyl)propyl>amine
Alimezine
dl-Trimeprazine
Teralen
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine
Trimeprazine

Biological Activity

[Description]:

Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays sedative, antiserotonin, antispasmodic, and antiemetic properties[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

HA receptor[1]

[References]

[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

[2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3).

Chemical & Physical Properties

[ Density]:
1.203 g/cm3

[ Boiling Point ]:
420.3ºC at 760mmHg

[ Melting Point ]:
68°C

[ Molecular Formula ]:
C₁₈H₂₂N₂S

[ Molecular Weight ]:
298.44600

[ Flash Point ]:
208ºC

[ Exact Mass ]:
298.15000

[ PSA ]:
31.78000

[ LogP ]:
4.55200

[ Water Solubility ]:
0.942 mg/L

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO5700000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-

CAS REGISTRY NUMBER :: 84-96-8

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2-S

MOLECULAR WEIGHT :: 298.48

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

REFERENCE :: DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4969 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 333 (estimated) No. of Female Employees: 227 (estimated)

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)