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Flumazenil acid

Names

[ CAS No. ]:
84378-44-9

[ Name ]:
Flumazenil acid

[Synonym ]:
Flumazenil acid
3-desmethylflumazenil
4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-
8-Fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
desethylflumazenyl
desethylflumazenil
Ro 15-3890

Biological Activity

[Description]:

Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Kleingeist B, et al. Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase. J Pharm Pharm Sci. 1998 Jan-Apr;1(1):38-46.

[2]. Mograbi KM, et al. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiol Rep. 2017 Mar;5(6). pii: e13081.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
570.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H10FN3O3

[ Molecular Weight ]:
275.24

[ Flash Point ]:
298.8±30.1 °C

[ Exact Mass ]:
275.070618

[ PSA ]:
75.43000

[ LogP ]:
-0.16

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.697

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds