CAY10471 Racemate

Names

[ Name ]:
CAY10471 Racemate

[Synonym ]:
3-[[(4-fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9h-carbazole-9-acetic acid

Biological Activity

[Description]:

CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[Target]

Ki: 0.6 nM (CRTH2), 200 nM (DP)[1]

[In Vitro]

CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formatio, suppresses β-arrestin translocation with IC50s of 12 and 3 nM, respectively[1].

[References]

[1]. Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁FN₂O₄S

[ Molecular Weight ]:
416.46600

[ Exact Mass ]:
416.12100

[ PSA ]:
87.99000

[ LogP ]:
4.12380

[ Storage condition ]:
2-8℃

CAY10471 Racemate

Names

Biological Activity

Chemical & Physical Properties

Related Compounds