HA-100

Names

[ Name ]:
HA-100

[Synonym ]:
Tocris-0543
ha-100
MFCD01310980

Biological Activity

[Description]:

HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), Protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Myosin

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

Research Areas >> Cancer

[Target]

PKC:12 μM (IC50)

PKG:4 μM (IC50)

PKA:8 μM (IC50)

MLCK:240 μM (IC50)

[References]

[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.332g/cm3

[ Boiling Point ]:
497.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₅N₃O₂S

[ Molecular Weight ]:
277.34200

[ Flash Point ]:
254.6ºC

[ Exact Mass ]:
277.08800

[ PSA ]:
70.68000

[ LogP ]:
2.17620

[ Index of Refraction ]:
1.639

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ RTECS ]:
TM0862600

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%