Acetoxyvalerenic acid

Names

[ Name ]:
Acetoxyvalerenic acid

[Synonym ]:
ACETOXYVALERENIC ACID
1-ACETOXYVALERENIC ACID
2-Propenoic acid, 3-[1-(acetyloxy)-2,4,5,6,7,7a-hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-, [1R-[1α,4α(E),7β,7aα]]-
Valerenolic acid, acetyl-
Acetoxyvalerenic acid
Acetylvalerenolic acid

Biological Activity

[Description]:

Acetoxyvalerenic acid is a natural compound that could be found in valerian[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Acetoxyvalerenic acid (AVA, 2 μM) and is most efficient in enhancing IGABA (183.1 ± 24.8 %)[1].

[References]

[1]. Gabriele Trauner, et al. Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Med. 2008 Jan;74(1):19-24.

[2]. Tania Lefebvre, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharm Sci. 2004 Aug 12;7(2):265-73.

Chemical & Physical Properties

[ Density]:
1.31 g/cm3

[ Molecular Formula ]:
C₁₇H₂₄O₄

[ Molecular Weight ]:
292.37000

[ Exact Mass ]:
292.16700

[ PSA ]:
63.60000

[ LogP ]:
3.33150

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Esters of valerenic acid as potential prodrugs.

Eur. J. Pharmacol. 735 , 123-31, (2014)

Valerenic acid (VA) is a β2/3 subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABAA) receptors inducing anxiolysis. Here we analyze if VA-esters can serve as prodrugs and if different...