Indazole-Cl

[Description]:

Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inﬂammation in vascular smooth muscle cells (VSMCs)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2

[In Vitro]

Indazole-Cl (0.1 μM；6 小时) 降低血管平滑肌细胞 (VSMC) 缺氧诱导的细胞内 ROS 水平[1]。 Indazole-Cl (10 μM；24 小时) 抑制 VSMC 中缺氧诱导的环氧合酶 (COX)-2 转录活性[1]。 Indazole-Cl (1 μM；24-72 小时) 可防止缺氧诱导的 VSMC 细胞迁移和侵袭[1]。

[References]

[1]. Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63(1):27-38.

[ Molecular Formula ]:
C₁₃H₉ClN₂O₂

[ Molecular Weight ]:
260.68

[ Exact Mass ]:
260.03500

[ PSA ]:
58.28000

[ LogP ]:
3.09010

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

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Cell 4 , 584-95, (2011)

Estrogen receptor transrepresses brain inflammation. Gosselin D, Rivest S.

Cell 4 , 495-7, (2011)

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