AIMP2-DX2-IN-1
Names
[ CAS No. ]:
848256-17-7
[ Name ]:
AIMP2-DX2-IN-1
Biological Activity
[Description]:
AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM[1].
[Related Catalog]:
[Target]
IC50: 0.1063 μM (AIMP2-DX2)[1]
[In Vitro]
AIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells[1]. AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved[1]. Cell Viability Assay[1] Cell Line: A549, H460 and WI-26 Concentration: 0-1 μM Incubation Time: 96 h Result: Showed inhibitory activities with EC50s of 0.690 ± 0.648 μM and 0.150 ± 0.062 μM against A549 and H460 cells, respectively. And is not active for WI-26.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H21NO3
[ Molecular Weight ]:
359.42