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Diquat (bromide)

Names

[ CAS No. ]:
85-00-7

[ Name ]:
Diquat (bromide)

[Synonym ]:
EINECS 201-579-4
DEIQUAT 1-HYDRATE
Diquat dibromide
6,7-dihydrodipyrido(1,2-a:2,1-c)pyrazinediium dibromide
deiquat dibromide
Reglox
DIQUAT-D4 DIBROMIDE
MFCD01074187
9,10-dihydro-8a,10a-diazoniaphenanthrene dibromide
DEIQUAT MONOHYDRATE
6,7-dihydrodipyrido[1,2-a:2’,1’-c]pyrazine-5,8-diium dibromide
DIQUAT DIBROMIDE-D4
diquat dication dibromide
Dquat
pp100
6,7-Dihydrodipyrido<1,2-a:2',1'-c>pyrazinium dibromide
1,1’-ethylene-2,2’-bipyridyldiylium dibromide
Diquat dibromide D4
DIQUATEDIBROMIDE
weedtrine-d
Reward
preeglone
DIQUATBROMIDE
ortho-diquat
6,7-dihydrodipyrido[1,2-a:2’,1’-c]pyrazinediium dibromide
reglon

Biological Activity

[Description]:

Diquat dibromide is a comprehensive herbicide commonly used in the cultivation of cotton, soybeans, and other crops to combat unwanted weeds. Diquat dibromide has an IC50 of 60 mg/L in the Allium root growth inhibition test[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Acar A. In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28(34):47550-47561.

Chemical & Physical Properties

[ Density]:
1.25

[ Melting Point ]:
330-340(分解)ºC

[ Molecular Formula ]:
C12H12BrN2+

[ Molecular Weight ]:
264.14100

[ Exact Mass ]:
263.01800

[ PSA ]:
7.76000

[ LogP ]:
1.90030

[ Water Solubility ]:
Soluble. 70 g/100 mL

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JM5690000
CHEMICAL NAME :
Dipyrido(1,2-a;2',1'-c)pyrazinediium, 6,7-dihydro-, dibromide
CAS REGISTRY NUMBER :
85-00-7
LAST UPDATED :
199806
DATA ITEMS CITED :
46
MOLECULAR FORMULA :
C12-H12-N2.2Br
MOLECULAR WEIGHT :
344.08
WISWESSER LINE NOTATION :
T B666 GK JK&T&J &Q 2 &E 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
433 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
564 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
988 mg/kg/19W-I
TOXIC EFFECTS :
Liver - other changes Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - isomerases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
7 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
15 mg/kg
SEX/DURATION :
female 17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
10800 ug/kg
SEX/DURATION :
female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 31(Suppl),214,1986 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.5 mg/m3 DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,17,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 0.5 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3 JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.5 mg/m3 JAN 1993 OEL-HUNGARY:STEL 0.1 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIQUAT-air:10H TWA 0.5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83281 No. of Facilities: 98 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 200 (estimated)

Safety Information

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R21;R25

[ Safety Phrases ]:
S36/37-S45

[ RIDADR ]:
UN 2781/2811

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2933990017

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933990017

[ Summary ]:
2933990017 6,7-dihydrodipyrido[1,2-a:2',1'-c]pyrazine-5,8-diium bromide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%


Related Compounds