HO-PEG5-CH2CH2COO<sup>t</sup>Bu

Names

[ Name ]:
HO-PEG5-CH2CH2COO<sup>t</sup>Bu

[Synonym ]:
18-Hydroxy-19-norcorticosterone
18-hydroxy-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester
18-OH-19-NC

Biological Activity

[Description]:

Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₄O₈

[ Molecular Weight ]:
366.44700

[ Exact Mass ]:
366.22500

[ PSA ]:
92.68000

[ LogP ]:
0.79350

HO-PEG5-CH2CH2COO<sup>t</sup>Bu

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds