Gaboxadol hydrochloride

Names

[ Name ]:
Gaboxadol hydrochloride

[Synonym ]:
Gaboxadol hydrochloride
Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrochloride (1:1)
4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one hydrochloride (1:1)

Biological Activity

[Description]:

Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

GABAA[1]

[References]

[1]. Zanettini C, et al. Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats. Psychopharmacology (Berl). 2016 May;233(10):2005-13.

Chemical & Physical Properties

[ Boiling Point ]:
295.7ºC at 760 mmHg

[ Melting Point ]:
236 °C

[ Molecular Formula ]:
C₆H₉ClN₂O₂

[ Molecular Weight ]:
176.601

[ Flash Point ]:
132.6ºC

[ Exact Mass ]:
176.035248

[ PSA ]:
58.03000

[ LogP ]:
0.74440

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NY3396800

Articles

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

J. Neurosci. 34(31) , 10361-78, (2014)

The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS underlies ...

Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.

Psychopharmacol. Ser. 232(8) , 1415-26, (2015)

Allopregnanolone (ALLO) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR). Ex...

Effects of gaboxadol on the expression of cocaine sensitization in rats.

Exp. Clin. Psychopharmacol. 24 , 131-41, (2016)

Behavioral sensitization to psychostimulants is associated with changes in dopamine (DA), glutamate, and GABA within the mesocorticolimbic and nigrostriatal DA systems. Because GABAA receptors are hig...