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Dovitinib (TKI-258) Dilactic Acid

Names

[ CAS No. ]:
852433-84-2

[ Name ]:
Dovitinib (TKI-258) Dilactic Acid

[Synonym ]:
Dovitinib (TKI-258) Dilactic Acid
Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone (2:1)
Dovitinib Dilactic acid
2-Hydroxypropanoic acid - 4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone (2:1)
TKI258 Dilactic acid
Dovitinib Dilacticacid

Biological Activity

[Description]:

Dovitinib (dilactic acid) is an orally active inhibitor of VEGF kinase. Dovitinib (dilactic acid) inhibits receptor tyrosine kinases (RTKs) involved in solid and hematologic cancers and tumor angiogenesis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. Zhu, S., et al. The Chemical Development of CHIR-258. CHIMIA International Journal for Chemistry, 60(9), 584–592.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H33FN6O7

[ Molecular Weight ]:
572.59

[ Exact Mass ]:
572.239502

[ PSA ]:
209.36000

[ LogP ]:
2.44450

[ Storage condition ]:
-20℃

Related Compounds