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TRAF6 Peptide trifluoroacetate salt

Names

[ CAS No. ]:
852805-92-6

[ Name ]:
TRAF6 Peptide trifluoroacetate salt

[Synonym ]:
L-Lysine, L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-α-glutamyl-L-seryl-L-alanyl-L-serylglycyl- L-prolyl-L-seryl-L-α-glutamyl-L-α-aspartyl-L-prolyl-L-seryl-L-valyl-L-asparaginyl-L-phenylalanyl-L-leucyl-
L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-α-glutamyl-L-seryl-L-alanyl-L-serylglycyl-L-prolyl-L -seryl-L-α-glutamyl-L-α-aspartyl-L-prolyl-L-seryl-L-valyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-lysine

Biological Activity

[Description]:

TRAF6 peptide is a specific TRAF6-p62 inhibitor. TRAF6 peptide potently abrogates NGF-dependent TrkA ubiquitination. TRAF6 peptide has good research potential in neurological diseases such as alzheimer's disease (AD), parkinson's, ALS, head trauma, epilepsy and stroke[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Research Areas >> Neurological Disease

[In Vitro]

TRAF6 peptide (150 µM; 5 h) blocks the interaction of p62 with TRAF6 in PC12 cells[1]. TRAF6 peptide eliminates TRAF6 and UbcH7 from interacting with TrkA and can ffectively abolish NGF-dependent ubiquitination of TrkA in vitro[1]. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 150 µM Incubation Time: 5 h Result: Inhibited the interaction of p62 with TRAF6 by immunoprecipitating TRA F6.

[References]

[1]. Wooten, Marie W. Substances interfering with TRAF6-p62 interaction for inhibiting intracellular aggregate formation and methods for screening for such substances. Patent WO2005050170A2.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
2698.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C145H238N34O44

[ Molecular Weight ]:
3161.643

[ Flash Point ]:
1585.8±34.3 °C

[ Exact Mass ]:
3159.743164

[ LogP ]:
5.04

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.556

Related Compounds