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Pyr-His-Pro-Gly-OH

Names

[ CAS No. ]:
85344-77-0

[ Name ]:
Pyr-His-Pro-Gly-OH

[Synonym ]:
PE-H-P-G
PYR-HIS-PRO-GLY-OH
THYROTROPIN-RELEASING HORMONE-GLY
pglu-his-pro-gly
PYR-HIS-PRO-GLY
GLP-HIS-PRO-GLY

Biological Activity

[Description]:

Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Thyroid Hormone Receptor

[In Vitro]

在表达内源性 TRH-R 的 GH3 细胞中，Trh-gly 引起细胞内钙浓度的立即升高，表明 Trh-gly 直接反应而不从 Trh-gly 转化为 TRH[2]。

[In Vivo]

在聚氨酯麻醉的 2 个月大（250 克）雄性 Sprague-Dawley 大鼠中，Trh-gly（脑池内注射；1.0 mg）导致下丘脑、延髓和血液中的 TRH 水平显着增加[1]。

[References]

[1]. A E Pekary, et al. Release of thyrotropin and prolactin by a thyrotropin-releasing hormone (TRH) precursor, TRH-Gly: conversion to TRH is sufficient for in vivo effects. Neuroendocrinology. 1990 Dec;52(6):618-25.  

[2]. M Yamada, et al. Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. Neurosci Lett. 1995 Aug 18;196(1-2):109-12.  

Chemical & Physical Properties

[ Density]:
1.461g/cm3

[ Boiling Point ]:
1069.5ºC at 760 mmHg

[ Molecular Formula ]:
C18H24N6O6

[ Molecular Weight ]:
420.42000

[ Flash Point ]:
600.6ºC

[ Exact Mass ]:
420.17600

[ PSA ]:
173.59000

[ Index of Refraction ]:
1.611

Related Compounds