Indanidine

Names

[ CAS No. ]:
85392-79-6

[ Name ]:
Indanidine

[Synonym ]:
Indanidinum
Unii-mp564ife34

Biological Activity

[Description]:

Indanidine is an alpha-adrenergic agonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Cardiovascular Disease

[Target]

alpha-adrenergic[1]

[In Vivo]

The selective alpha 1-adrenoceptor agonist, Indanidine, also behaved as a partial agonist in the aorta and produced no significant contractions of the small mesenteric artery. Since Idazoxan and Indanidine have been reported to raise blood pressure in the pithed rat via an action at vascular alpha 1-adrenoceptors, these results call into question the reliability of the small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity in vivo[1].

[References]

[1]. Van der Graaf PH, et al. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):389-92.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
413.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₃N₅

[ Molecular Weight ]:
215.25400

[ Flash Point ]:
203.8ºC

[ Exact Mass ]:
215.11700

[ PSA ]:
54.24000

[ LogP ]:
0.78180

[ Index of Refraction ]:
1.738

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%