N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamidehydrochloride

Names

[ Name ]:
N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamidehydrochloride

[Synonym ]:
CBiPES

Biological Activity

[Description]:

CBiPES hydrochloride is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

EC50: 92.8 nM (mGlu2 receptor)[1]

[References]

[1]. Johnson MP, et al. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology (Berl). 2005 Apr;179(1):271-83.

[2]. Frouni I, et al. Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. J Neural Transm (Vienna). 2021 Jan;128(1):73-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₀ClN₃O₂S

[ Molecular Weight ]:
413.92

[ Exact Mass ]:
413.09600

[ PSA ]:
82.44000

[ LogP ]:
5.85938

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport