inosine 5'-(trihydrogen diphosphate)

Names

[ CAS No. ]:
86-04-4

[ Name ]:
inosine 5'-(trihydrogen diphosphate)

[Synonym ]:
O5'-trihydroxydiphosphoryl-inosine
riboxine
Inosindiphosphat
Inosine 5'-pyrophosphate
Inosin-5'-diphosphat
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate
Inosine diphosphate
Inosine 5'-diphosphate
5'-inosine diphosphate
Riboxin

Biological Activity

[Description]:

Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vivo]

Riboxin (250 mg/kg; 口服; 单剂量) 可增加小鼠的游泳时间，但对力量耐力无显著影响。在相同条件下，Riboxin 提高了热室实验中动物的存活率[1]。 Riboxin (50 mg/kg; 口服; 每天1次，持续6天) 增加小鼠游走的时间，而对游泳和跑步的时间无显著影响[1]。 Riboxin (250 mg/kg; 口服; 实验前 1 小时) 对小鼠有明显的 γ 辐照保护作用[1]。

[References]

[1]. Sokolov I K, et al. Adaptogenic effect of riboxin[J]. Pharmaceutical Chemistry Journal, 1980, 14(1): 34-39.

[2]. Veveris M, et al. Experimental study of the antiarrhythmic effect of riboxin. Farmakol. Neirotropnykh Sredstv (1978), 119-24.

Chemical & Physical Properties

[ Density]:
2.49g/cm3

[ Boiling Point ]:
925.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₃N₄O₁₅P₃--

[ Molecular Weight ]:
522.14900

[ Flash Point ]:
513.3ºC

[ Exact Mass ]:
521.95900

[ PSA ]:
328.66000

[ Index of Refraction ]:
1.883

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM7515000

CHEMICAL NAME :: Inosine 5'-(trihydrogen pyrophosphate)

CAS REGISTRY NUMBER :: 86-04-4

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H14-N4-O11-P2

MOLECULAR WEIGHT :: 428.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 51,100,1988