Indigo carmine

Names

[ CAS No. ]:
860-22-0

[ Name ]:
Indigo carmine

[Synonym ]:
Disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)indoline-5-sulfonate
Indigo-5,5'-disulfonic acid disodium salt
FD and C blue 2
indigotini
Indigo Carmine
Indigo-5,5′-disulfonic acid disodium salt
Disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-5-indolinesulfonate
1H-indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, disodium salt, (2E)-
murabba
1H-Indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, sodium salt, (2E)- (1:2)
E132
Greell S
Indigotine
Indigotindisulfonate Sodium
Disodium 5,5'-indigotin disulfonate
l-blau2
Sodium 3,3'-dioxo-[2,2'-biindolinylidene]-5,5'-disulfonate
disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate
Food Blue No. 2
FD & C blue no. 2
1311blue
EINECS 212-728-8
acidbluew
E 132
trans-indigo carmine
indigo carmin
MFCD00005723
Emtricitabine Impurity 4

Biological Activity

[Description]:

Indigo carmine is an efficient reagent for the determination of ozone by chemlluminescence (CL)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Indigo carmine in a 0.2% aqueous solution is blue at pH 11.4 and yellow at 13.0. Indigo carmine is also a redox indicator, turning yellow upon reduction[1].

[References]

[1]. K Takeuchi, et al. Quantitative Determination of Aqueous-Phase Ozone by Chemiluminescence Using indigo-5,5'-disulfonate. Anal Chem. 1989 Mar 15;61(6):619-23.

Chemical & Physical Properties

[ Density]:
1.01 g/mL at 20 °C

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C₁₆H₈N₂Na₂O₈S₂

[ Molecular Weight ]:
466.353

[ Exact Mass ]:
465.951752

[ PSA ]:
189.36000

[ LogP ]:
3.06060

[ Index of Refraction ]:
n20/D 1.335

[ Water Solubility ]:
1 g/100 mL (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU3000000

CHEMICAL NAME :: (delta(sup 2,2')-Biindoline)-5,5'-disulfonic acid, 3,3'-dioxo-, disodium salt

CAS REGISTRY NUMBER :: 860-22-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C16-H8-N2-O8-S2.2Na

MOLECULAR WEIGHT :: 466.36

WISWESSER LINE NOTATION :: T56 BMYVJ GSWO CU- CT56 BMYVJ GSWO &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 405 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84752 No. of Facilities: 314 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 1736 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84752 No. of Facilities: 393 (estimated) No. of Industries: 7 No. of Occupations: 28 No. of Employees: 9691 (estimated) No. of Female Employees: 3035 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DU3000000

[ HS Code ]:
32041200

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Intraluminal injection of indigo carmine facilitates identification of the afferent limb during double-balloon ERCP.

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