MK-0249

Names

[ CAS No. ]:
862309-06-6

[ Name ]:
MK-0249

[Synonym ]:
2-methyl-(3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone)
2-methyl-3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone
MK-0249

Biological Activity

[Description]:

MK-0249 is a potent histamine H3 receptor antagonist, with Ki of 1.7 nM for human H3.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 1.7 nM (Human H3)[1]


[References]

[1]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.


[Related Small Molecules]

Loratadine | Histamine | Pitolisant hydrochloride | Cimetidine | Osthole | Clemastine fumarate | Ebrotidine | JNJ-7777120 | Famotidine | Cetirizine Dihydrochloride | Desloratadine | Ketotifen fumarate | Lodoxamide | Meclizine dihydrochloride | Chlorpheniramine maleate

Chemical & Physical Properties

[ Molecular Formula ]:
C23H24F3N3O2

[ Molecular Weight ]:
431.45100

[ Exact Mass ]:
431.18200

[ PSA ]:
47.36000

[ LogP ]:
4.51550

[ Storage condition ]:
2-8℃

Related Compounds