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GSK-3β inhibitor 14

Names

[ CAS No. ]:
863004-48-2

[ Name ]:
GSK-3β inhibitor 14

[Synonym ]:
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-

Biological Activity

[Description]:

GSK-3β inhibitor 14 (Compound 6i), benzothiazepinone derivative, is a weak GSK-3β inhibitor (IC50 >100 μM)[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[References]

[1]. Zhang P, et al. Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β). Eur J Med Chem. 2013 Mar;61:95-103.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17NOS

[ Molecular Weight ]:
283.39