3-(Methylselanyl)-L-alanine hydrochloride (1:1)

Names

[ Name ]:
3-(Methylselanyl)-L-alanine hydrochloride (1:1)

[Synonym ]:
Se-MSC
M 6680
L-Alanine, 3-(methylseleno)-, hydrochloride (1:1)
3-(Methylselanyl)-L-alanine hydrochloride (1:1)

Biological Activity

[Description]:

Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

[References]

[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

[2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.

[3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄H₁₀ClNO₂Se

[ Molecular Weight ]:
218.54

[ Exact Mass ]:
218.956528

[ PSA ]:
63.32000

[ LogP ]:
1.07120

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H331-H373-H410

[ Precautionary Statements ]:
P261-P273-P301 + P310-P311-P501

[ Hazard Codes ]:
T

[ RIDADR ]:
UN 3283 6.1 / PGII

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms.

Metallomics 8 , 305-12, (2016)

Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been ...

Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells.

Mol. Cell Biochem. 327 , 111-26, (2009)

Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing extracellular antioxidant protein that catalyzes the reduction of hydrogen peroxide and lipid hydroperoxides. Selenoprotein express...