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5,8-Epidioxyergosta-6,9(11),22-trien-3-ol

Names

[ CAS No. ]:
86363-50-0

[ Name ]:
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol

Biological Activity

[Description]:

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[Target]

Microbial Metabolite


[In Vitro]

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide) is an effective inhibitor of HL60 leukemia cell growth and apoptosis-inducer[1]. Apoptosis induced by 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent[2].

[References]

[1]. Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9(11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29(4):755-759.

[2]. Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18(1):938-944.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H42O3

[ Molecular Weight ]:
426.63100

[ Exact Mass ]:
426.31300

[ PSA ]:
38.69000

[ LogP ]:
6.39370

Related Compounds