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ZIP

Names

[ CAS No. ]:
863987-12-6

[ Name ]:
ZIP

[Synonym ]:
Zinc dimethylcarbamodithioate cyclohexanamine (1:2:1)
(Cyclohexylamine)bis(dimethyldithiocarbamato-S,S')zinc
EINECS 240-577-8
Zinc,dimethyldithiocarbamate cyclohexylamine complex
Ziram,cyclohexylamine complex
Zinc dimethylcarbamodithioate - cyclohexanamine (1:2:1)
Zinc bis(dimethyldithiocarbamate)cyclohexylamine complex
Caswell No. 931A
Zinc,(cyclohexylamine)bis(dimethyldithiocarbamato)

Biological Activity

[Description]:

ZIP is a selective peptide inhibitor of PKMζ. ZIP injections can block the impairment in morphine conditioned place preference induced[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Neurological Disease
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKMζ[1]


[References]

[1]. Li Y, et, al. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31(14):5436-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H25N3S4Zn

[ Molecular Weight ]:
405.016

[ Exact Mass ]:
403.022278

[ PSA ]:
96.68000

[ LogP ]:
2.73520

Related Compounds