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1,4-DPCA ethyl ester

Names

[ CAS No. ]:
86443-19-8

[ Name ]:
1,4-DPCA ethyl ester

[Synonym ]:
ethyl 1-benzyl-4-oxonipecotate
ethyl N-benzyl-4-oxo--3-piperidinecarboxylate
ethyl 4-oxo-1-benzylpiperidine-3-carboxylate
ethyl 1,4-dihydro-4-oxo-1,10-phenanthroline-3-carboxylate
1-Benzyl-3-ethoxycarbonyl-4-piperidone
ethyl-N-benzyl-4-oxo-piperidinecarboxylate
ethyl1-benzyl-4-oxopiperidine-3-carboxylate
1-Benzyl-3-carboethoxy-4-piperidone
ethyl 4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylate
1-Benzyl-3-carbethoxy-4-piperidone

Biological Activity

[Description]:

1,4-DPCA ethyl ester is the ethyl ester of 1,4-DPCA and can inhibit factor inhibiting HIF (FIH)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[In Vitro]

1,4-DPCA ethyl ester is a tricyclic compound that inhibits factor inhibiting HIF (FIH)[1].

[References]

[1]. Biswadip Banerji, et al. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. Chem Commun (Camb). 2005 Nov 21;(43):5438-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H12N2O3

[ Molecular Weight ]:
268.26700

[ Exact Mass ]:
268.08500

[ PSA ]:
72.05000

[ LogP ]:
2.25300

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds