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4-oxo-4-HPR

Names

[ CAS No. ]:
865536-65-8

[ Name ]:
4-oxo-4-HPR

[Synonym ]:
4-oxo-4-HPR
N-(4-Hydroxyphenyl)-4-oxoretinamide
4-oxo-N-(4-hydroxyphenyl)retinamide
3-Keto fenretinide
4-Oxo Fenretinide
4-Keto-4-HPR

Biological Activity

[Description]:

4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. VillaniMG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitiveand fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.  

[2]. Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.  

Chemical & Physical Properties

[ Density]:
1.131g/cm3

[ Boiling Point ]:
641.8ºC at 760 mmHg

[ Molecular Formula ]:
C26H31NO3

[ Molecular Weight ]:
405.53

[ Flash Point ]:
341.9ºC

[ Exact Mass ]:
405.23000

[ PSA ]:
66.40000

[ LogP ]:
6.11430

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20℃

Related Compounds