URB754

Names

[ Name ]:
URB754

[Synonym ]:
6-methyl-2-(4-toluidino)-4H-3,1-benzoxazin-4-one
6-methyl-2-(4-methylanilino)-3,1-benzoxazin-4-one
6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
4H-3,1-Benzoxazin-4-one, 6-methyl-2-[(4-methylphenyl)amino]-
URB754

Biological Activity

[Description]:

URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC50 of 200 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Tarzia G, et al. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007;97(9):887-894.

[2]. Tarzia G, et al. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007;97(9):887-894.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
434.0±48.0 °C at 760 mmHg

[ Melting Point ]:
238-240ºC

[ Molecular Formula ]:
C₁₆H₁₄N₂O₂

[ Molecular Weight ]:
266.295

[ Flash Point ]:
216.3±29.6 °C

[ Exact Mass ]:
266.105530

[ PSA ]:
55.13000

[ LogP ]:
3.54

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.627

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%