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Biphenylindanone A

Names

[ CAS No. ]:
866823-73-6

[ Name ]:
Biphenylindanone A

[Synonym ]:
LS-193,571
BINA
[1,1'-Biphenyl]-4-carboxylic acid, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-
3'-{[(2-Cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl}-4-biphenylcarboxylic acid
cc-230
Biphenylindanone A

Biological Activity

[Description]:

Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR2


[In Vitro]

Biphenylindanone A (BINA) shows activity on glutamate-induced scintillation proximity assay [3H]IP1 hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate[1].

[References]

[1]. Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site. J Pharmacol Exp Ther. 2008 Jul;326(1):240-51.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
676.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H30O4

[ Molecular Weight ]:
454.557

[ Flash Point ]:
225.8±25.0 °C

[ Exact Mass ]:
454.214417

[ PSA ]:
63.60000

[ LogP ]:
8.27

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.627

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds