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Benzyl-PEG5-amine

Names

[ CAS No. ]:
86770-77-6

[ Name ]:
Benzyl-PEG5-amine

[Synonym ]:
2,5,8,11,14-Pentaoxahexadecan-16-amine, 1-phenyl-
MFCD28976656
1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-amine

Biological Activity

[Description]:

Benzyl-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
429.7±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H29NO5

[ Molecular Weight ]:
327.416

[ Flash Point ]:
210.7±21.0 °C

[ Exact Mass ]:
327.204559

[ LogP ]:
-0.03

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.498

Related Compounds