HDSF

Names

[ Name ]:
HDSF

[Synonym ]:
Hexadecanesulfonyl fluoride
Hexadecylsulfonyl fluoride
hdsf
palmitylsulphonylfluoride
Palmitylsulfonyl Fluoride
AM 374
1-HEXADECYLSULFONYL FLUORIDE

Biological Activity

[Description]:

AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> FAAH

[Target]

IC50: 13 nM (amidase)[1]

[In Vitro]

AM 374 (0-9 nM) 抑制 N18TG2 细胞中 anandamide 分解[1]。

[In Vivo]

AM 374 (20 μg；心室内注射，1 次) 对 FR5 杠杆按压无影响，但与 anandamide (腹腔注射) 共同使用时减少杠杆按压[2]。 Animal Model: Adult male Sprague-Dawley rats with lever press training[2] Dosage: 20 μg Administration: Intraventricular (ICV) injection; 20 μg, once Result: Significantly reduced lever pressing when combined treatment with anandamide.

[References]

[1]. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21.

[2]. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11.

Chemical & Physical Properties

[ Density]:
0.966g/cm3

[ Boiling Point ]:
388.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₃FO₂S

[ Molecular Weight ]:
308.49500

[ Flash Point ]:
188.6ºC

[ Exact Mass ]:
308.21900

[ PSA ]:
42.52000

[ LogP ]:
6.84780

[ Index of Refraction ]:
1.445

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2904909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2904909090

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%