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ICI141292

Names

[ CAS No. ]:
86880-51-5

[ Name ]:
ICI141292

[Synonym ]:
Epanololum [Latin]
(+-)-N-(2-((3-(o-Cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-2-(p-hydroxyphenyl)acetamide
Visacor
Epanololum
Benzeneacetamide,N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-4-hydroxy
Epanolol
ICI141292

Biological Activity

[Description]:

ICI141292 is a potent β-adrenoceptor partial agonist with a greater affinity for β1- than β2-adrenoceptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Cardiovascular Disease

[Target]

β1 adrenoceptor[1]


[In Vitro]

ICI141292 (Epanolol) is a novel anti-anginal agent which is a β1-adrenoceptor partial agonist exhibiting selective β1-adrenoceptor antagonist and selective β1-adrenoceptor agonist activity[1].

[References]

[1]. Hosie J, et al. Pharmacokinetics of epanolol after acute and chronic oral dosing in elderly patients with stable angina pectoris. Br J Clin Pharmacol. 1990 Mar;29(3):333-7.


[Related Small Molecules]

Isoprenaline hydrochloride | ICI 118,551 (hydrochloride) | Phenylephrine hydrochloride | Yohimbine hydrochloride | Adrenaline | Ivabradine hydrochloride | Prazosin hydrochloride | Clenbuterol hydrochloride | Phentolamine mesilate | guanfacine hydrochloride | pimozide | Sotalol hydrochloride | Carvedilol | Atenolol | Metroprolol succinate

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
689.7ºC at 760mmHg

[ Molecular Formula ]:
C20H23N3O4

[ Molecular Weight ]:
369.41400

[ Flash Point ]:
370.9ºC

[ Exact Mass ]:
369.16900

[ PSA ]:
114.61000

[ LogP ]:
1.73388

[ Index of Refraction ]:
1.617

Related Compounds