RSV L-protein-IN-3

Names

[ CAS No. ]:
868860-35-9

[ Name ]:
RSV L-protein-IN-3

Biological Activity

[Description]:

RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> RSV

[Target]

IC50: 10.4 μM (RSV)[1]


[References]

[1]. Michel Liuzzi, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005, 79(20).  

[2]. Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023，14，8.

[3]. Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.  

Chemical & Physical Properties

[ Molecular Formula ]:
C31H34N4O4

[ Molecular Weight ]:
526.63

Related Compounds