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A 841720

Names

[ CAS No. ]:
869802-58-4

[ Name ]:
A 841720

[Synonym ]:
BU 224 hydrochloride

Biological Activity

[Description]:

A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

Human mGluR1:10 nM (IC50)

human mGluR5:342 nM (IC50)


[References]

[1]. O El-Kouhen, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006 Nov;149(6):761-74.

[2]. Lorenzo Morè, et al. Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18(4):273-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H21N5OS

[ Molecular Weight ]:
343.44700

[ Exact Mass ]:
343.14700

[ PSA ]:
82.50000

[ LogP ]:
2.64920

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds