2-Hydroxyethyl salicylate

Names

[ CAS No. ]:
87-28-5

[ Name ]:
2-Hydroxyethyl salicylate

[Synonym ]:
Benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester
2-Hydroxybenzoic Acid 2-Hydroxyethyl Ester
ETHYLENE GLYCOL SALICYLATE
β-Hydroxyethyl salicylate
Monoglycol salicylate
Glycol salicylate (JAN)
Norgesic
2-hydroxyethyl 2-hydroxybenzoate
Salicylic acid, 2-hydroxyethyl ester
Phlogont
Glysal
Salicylic acid, 2-hydroxyethyl ester (8CI)
EINECS 201-737-2
2-Hydroxyethyl salicylate
MFCD00002862
SPIROSAL
GL 7
Glycol salicylate

Biological Activity

[Description]:

Glycol salicylate is a derivative of salicylic acid and can be used to improve the aesthetic appearance of the skin, extracted from patent US 20150148320 A1.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[References]

[1]. Kai Xi, et al. Cosmetic use of salicylic acid derivatives. US 20150148320 A1.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
294.3±0.0 °C at 760 mmHg

[ Melting Point ]:
25°C

[ Molecular Formula ]:
C₉H₁₀O₄

[ Molecular Weight ]:
182.173

[ Flash Point ]:
128.3±15.8 °C

[ Exact Mass ]:
182.057907

[ PSA ]:
66.76000

[ LogP ]:
1.16

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.573

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918230000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918230000

[ Summary ]:
2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

[On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)].

Derm. Beruf Umwelt. 29(6) , 161-7, (1981)

Three radioactively marked substances (on the basis of a carbopol gel, 80% water - isopropanol) were analyzed comparatively in regard to the penetration of ethyleneglycolmonosalicylate and benzylnicot...

[Therapy of rheumatic disease with a hydroxyethylsalicylate gel. Results of 2 clinical studies of effectiveness and bioavailability].

Fortschr. Med. 113(8) , 111-3, (1995)

Two clinical studies were carried out to investigate the efficacy and safety as well as the local and systemic availability of a hydroxyethylsalicyclate gel. A double blind, multicenter trial, involvi...

Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

J. Pharm. Biomed. Anal. 60 , 51-8, (2012)

Capsaicinoids, salicylic acid, methyl and ethyl salicylate, glycol monosalicylate, camphor and l-menthol are widely used in topical formulations to relieve local pain. For each separate compound or si...