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AMG-Tie2-1

Names

[ CAS No. ]:
870223-96-4

[ Name ]:
AMG-Tie2-1

[Synonym ]:
4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide
AMG-Tie2
4-Methyl-3-({3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide
4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide
pyridylpyrimidine ether 4
AMG-Tie2-1
Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-

Biological Activity

[Description]:

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C25H20F3N5O2

[ Molecular Weight ]:
479.454

[ Exact Mass ]:
479.156921

[ PSA ]:
95.75000

[ LogP ]:
4.78

[ Index of Refraction ]:
1.630

Related Compounds