(2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine

Names

[ Name ]:
(2S,3S)-N-benzyl-1,1-dimethoxy-N,3-dimethylpentan-2-amine

[Synonym ]:
Benzenemethanamine, N-[(1S,2S)-1-(dimethoxymethyl)-2-methylbutyl]-N-methyl-
MFCD28385889
(2S,3S)-N-Benzyl-1,1-dimethoxy-N,3-dimethyl-2-pentanamine

Biological Activity

[Description]:

Monomethyl auristatin E intermediate-12 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
329.1±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₇NO₂

[ Molecular Weight ]:
265.391

[ Flash Point ]:
106.1±10.7 °C

[ Exact Mass ]:
265.204193

[ LogP ]:
2.59

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.492