Neuromedin B trifluoroacetate salt

Names

[ Name ]:
Neuromedin B trifluoroacetate salt

[Synonym ]:
GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O
NEUROMEDIN B,PORCINE
GNLWATGHFM-NH2
Gly-L-Asn-L-Leu-L-Trp-L-Ala-L-Thr-Gly-L-His-L-Phe-L-Met-NH2
H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
NEUROMEDIN B,PORCINE MAMMALIAN BOMBESIN-LI
neuromedin-B
Neuromedin B

Biological Activity

[Description]:

Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Peptides

[In Vitro]

Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB)[1].

[In Vivo]

Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively[1].

[References]

[1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.337 g/cm3

[ Boiling Point ]:
1697.4ºC

[ Molecular Formula ]:
C₅₂H₇₃N₁₅O₁₂S

[ Molecular Weight ]:
1132.29000

[ Flash Point ]:
980.3ºC

[ Exact Mass ]:
1131.53000

[ PSA ]:
464.10000

[ LogP ]:
2.05180

[ Index of Refraction ]:
1.613

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice.

Endocrinology 155(7) , 2492-9, (2014)

The hypothalamic-pituitary-adrenal (HPA) axis is a major part of the neuroendocrine system that controls responses to stress, and has an important function in the regulation of various body processes....

Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts.

J. Endocrinol. 217(2) , 141-50, (2013)

Neuromedin B (NMB) is a mammalian bombesin-like peptide that regulates exocrine/endocrine secretion, smooth muscle contraction, body temperature, and the proliferation of some cell types. Here, we sho...

Effect of potential on temperature-dependent SERS spectra of neuromedin B on Cu electrode.

Phys. Chem. Chem. Phys. 15(3) , 807-15, (2013)

Adsorption of decapeptide neuromedin B (NMB) on copper electrode has been investigated by in situ surface-enhanced Raman scattering (SERS) spectroelectrochemistry in the temperature interval from 12 t...