Fmoc-NH-PEG2-CH2CH2COOH

Names

[ Name ]:
Fmoc-NH-PEG2-CH2CH2COOH

[Synonym ]:
3-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]propanoic acid
2,7,10-Trioxa-4-azatridecan-13-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-
3-{2-[2-Amino-3-(9H-fluoren-9-ylmethoxy)-3-oxopropoxy]ethoxy}propanoic acid
Serine, O-[2-(2-carboxyethoxy)ethyl]-, 9H-fluoren-9-ylmethyl ester
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oic acid
Fmoc-NH-PEG2-CH2CH2COOH

Biological Activity

[Description]:

Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Fulcher JM, et al. Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag. Org Biomol Chem. 2019 Dec 28;17(48):10237-10244.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
622.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₅NO₆

[ Molecular Weight ]:
399.437

[ Flash Point ]:
330.0±31.5 °C

[ Exact Mass ]:
399.168182

[ PSA ]:
97.58000

[ LogP ]:
2.96

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Storage condition ]:
-20 ℃

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%