MEDICA 16

Names

[ Name ]:
MEDICA 16

[Synonym ]:
3,3,14,14-Tetramethylhexanedecanedioic acid
3,3,14,14-tetramethyl-1,16-hexadecanedioic acid
MEDICA 16
Medic-16
3,3,14,14-tetramethyl-hexadecanedioic acid
3,3,14,14-Tetramethylhexadecanedioic acid
Hexadecandioic acid,3,3,14,14-tetramethyl
3,3,14,14-tetramethyl-hexadecane-1,16-dioic acid
Hexadecanedioic acid, 3,3,14,14-tetramethyl-
MFCD00797684

Biological Activity

[Description]:

MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR120

Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase

Signaling Pathways >> GPCR/G Protein >> GPR40

Research Areas >> Metabolic Disease

[References]

[1]. Atkinson LL, et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes. 2002;51(5):1548-1555.

[2]. Hara T, Hirasawa A, Sun Q, et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009;380(3):247-255.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
485.9±18.0 °C at 760 mmHg

[ Melting Point ]:
154-159ºC

[ Molecular Formula ]:
C₂₀H₃₈O₄

[ Molecular Weight ]:
342.513

[ Flash Point ]:
261.8±17.7 °C

[ Exact Mass ]:
342.277008

[ PSA ]:
74.60000

[ LogP ]:
6.44

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.474

MSDS

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Safety Information

[ HS Code ]:
2917190090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%