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Ganoderone A

Names

[ CAS No. ]:
873061-79-1

[ Name ]:
Ganoderone A

[Synonym ]:
Lanosta-8,24-diene-3,7-dione, 26-hydroxy-, (24E)-
(24E)-26-Hydroxylanosta-8,24-diene-3,7-dione
GANODERONE A

Biological Activity

[Description]:

Ganoderone A is a triterpene compound that can be isolated from the fruiting body of Ganoderma pfeifferi and Ganoderma calidophilum. Ganoderone A has antiviral activity against HSV with IC50 value of 0.3 µg/mL. Ganoderone A has potential applications in viral infections and tumors[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection

[Target]

HSV:0.3 μg/mL (IC50)


[In Vitro]

Ganoderone A 对 K562、BEL7402 和 SGC790 细胞系展现出细胞毒性活性，IC50 值分别为 7.62 µM、6.28 µM 和 3.55 µM[3]。

[References]

[1]. Niedermeyer TH, et al. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod. 2005 Dec;68(12):1728-31.  

[2]. Huang S Z, et al. Anti-allergic prenylated hydroquinones and alkaloids from the fruiting body of Ganoderma calidophilum[J]. RSC advances, 2016, 6(25): 21139-21147.

[3]. Huang SZ, et al. Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. Phytochemistry. 2017 Nov;143:104-110.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
568.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H46O3

[ Molecular Weight ]:
454.684

[ Flash Point ]:
311.4±26.6 °C

[ Exact Mass ]:
454.344696

[ LogP ]:
6.79

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.542

Related Compounds