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L-741,742 hydrochloride

Names

[ CAS No. ]:
874882-93-6

[ Name ]:
L-741,742 hydrochloride

[Synonym ]:
Methimepip dihydrobromide
L-741,742 hydrochloride
Piperidine, 4-[5-(4-chlorophenyl)-4-methyl-3-isoxazolyl]-1-(2-phenylethyl)-, monohydrochloride

Biological Activity

[Description]:

L 741742 hydrochloride is an orally active and selective antagonist of hD4 receptors. L 741742 hydrochloride has a good brain penetration. L 741742 hydrochloride can be used in study nervous system disorders, particularly schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[References]

[1]. Rowley M, et al. 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J Med Chem. 1997 Jul 18;40(15):2374-85.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H26Cl2N2O

[ Molecular Weight ]:
417.37

[ Exact Mass ]:
416.14200

[ PSA ]:
29.27000

[ LogP ]:
6.46540

Related Compounds