10-Nitro Oleic Acid

Names

[ Name ]:
10-Nitro Oleic Acid

[Synonym ]:
10-Nitro Oleic Acid

Biological Activity

[Description]:

10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

10-Nitrooleic acid (5-25 μM; mouse keratinocytes) regulates expression of HO-1, hsp27, hsp70, Cox-2, and the glutathione-S-transferases GSTA1-2, GSTA3 and GSTA4 in a generally similar manner[1]. 10-Nitrooleic acid (10 μM; 0-6 hours) upregulates HO-1 protein in time- and concentration-dependent manners. 10-Nitrooleic acid also upregulates protein expression for Cox-2, hsp27, hsp70[1].

[References]

[1]. Garner RM, Mould DR, Chieffo C, Jorkasky DK. Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects. Clin Transl Sci. 2019;12(6):667-676.

[2]. Zheng R, et al. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 2014;67:1-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₃₃NO₄

[ Molecular Weight ]:
327.46

[ Exact Mass ]:
327.24100

[ PSA ]:
83.12000

[ LogP ]:
6.23610

10-Nitro Oleic Acid

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds