1-(4-Hydroxy-3-methylphenyl)ethanone

Names

[ CAS No. ]:
876-02-8

[ Name ]:
1-(4-Hydroxy-3-methylphenyl)ethanone

[Synonym ]:
4-hydroxy-5-methylacetophenone
4-HYDROXY-3-METHYLACETOPHENONE
3'-methyl-4'-hydroxyacetophenone
4-ACETYL-2-METHYLPHENOL
4-hydroxy-3-methylphenyl methyl ketone
Ethanone, 1-(4-hydroxy-3-methylphenyl)-
p-hydroxy-m-methylacetophenone
EINECS 212-880-5
2-methyl-4-acetylphenol
4'-Hydroxy-3'-methyl
MFCD00002231
1-(4-Hydroxy-3-methylphenyl)ethanone

Biological Activity

[Description]:

4'-Hydroxy-3'-methylacetophenone, a phenolic volatile compound, is isolated from Hawaiian green coffee beans (Coffea Arabica L.). 4'-Hydroxy-3'-methylacetophenone has potent antioxidant activities. 4'-Hydroxy-3'-methylacetophenone also can be used to synthesize heterocyclic compounds which have antimycobacterial activity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Lee KG, et, al. Analysis of volatile components isolated from Hawaiian green coffee beans (Coffea arabica L.). Flavour and Fragrance Journal. 2002 Sep; 17 (5): 349-351.

[2]. YAR MS, et, al. Synthesis and antimycobacterial activity of novel heterocycles. J. Serb. Chem. Soc. 72 (1) 5-11 (2007).

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
301.6±22.0 °C at 760 mmHg

[ Melting Point ]:
107-109 °C(lit.)

[ Molecular Formula ]:
C₉H₁₀O₂

[ Molecular Weight ]:
150.174

[ Flash Point ]:
127.3±14.9 °C

[ Exact Mass ]:
150.068085

[ PSA ]:
37.30000

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.546

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S36/37/39-S26-S22-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...