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Revefenacin

Names

[ CAS No. ]:
876296-47-8

[ Name ]:
Revefenacin

[Synonym ]:
Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-6-oxo-L-lysyl-L-asparaginyl-L-cysteinyl-L-prolyl-N5-(1-methylethyl)-L-ornithyl-, cyclic (1→6)-disulfide
8P2T76M0SJ
[2-L-phenylalanine,3-L-isoleucine,4-(6-oxo-L-lysine),8-[5-N-(1-methylethyl)-L-ornithine]]human vasopressin
9418
1-({(4R,7S,10S,13S,16S,19R)-19-Amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-[(2S)-2-butanyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-pro ;lyl-N5-isopropyl-L-ornithylglycinamide
Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloe ;icos-4-yl]carbonyl]-L-prolyl-N5-(1-methylethyl)-L-ornithyl-
SELEPRESSIN
FE 202158

Biological Activity

[Description]:

Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

[In Vitro]

Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[3]. Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[3]. Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[3]. Western Blot Analysis[2] Cell Line: HLMVECs Concentration: 1, 10, 100, 1000 nM Incubation Time: 24 h, 48 h Result: Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.

[In Vivo]

Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[4]. Animal Model: LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. Dosage: 1 μg/kg/min Administration: Left jugular vein infusion for 12 min Result: Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1512.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C46H73N13O11S2

[ Molecular Weight ]:
1048.282

[ Flash Point ]:
868.3±34.3 °C

[ Exact Mass ]:
1047.499390

[ LogP ]:
-3.83

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.545

Related Compounds