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Trityl-PEG10-azide

Names

[ CAS No. ]:
877239-08-2

[ Name ]:
Trityl-PEG10-azide

[Synonym ]:
31-Azido-1,1,1-triphenyl-2,5,8,11,14,17,20,23,26,29-decaoxahentriacontane
MFCD22683292
2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane, 31-azido-1,1,1-triphenyl-

Biological Activity

[Description]:

Trityl-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C39H55N3O10

[ Molecular Weight ]:
725.868

[ Exact Mass ]:
725.388733

[ LogP ]:
3.18

Related Compounds