Anti-inflammatory agent 42

Names

[ Name ]:
Anti-inflammatory agent 42

[Synonym ]:
2-Naphthalen-1-ylmethylene-benzo[4,5]imidazo[2,1-b]thiazol-3-one
Thiazolo[3,2-a]benzimidazol-3(2H)-one, 2-(1-naphthylmethylene)-
(2Z)-2-(1-Naphthylmethylene)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
Thiazolo[3,2-a]benzimidazol-3(2H)-one, 2-(1-naphthalenylmethylene)-, (2Z)-

Biological Activity

[Description]:

Anti-inflammatory agent 42 (Compound 10j) is an anti-inflammatory agent. Anti-inflammatory agent 42 shows excellent inhibition on the expression of TNF-α and IL-6 in LPS (HY-D1056)-stimulated macrophages[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[In Vitro]

Anti-inflammatory agent 42 (Compound 10j; 10 μM; 2 h) 抑制 LPS 诱导的 RAW 264.7 巨噬细胞 TNF-α 和 IL-6 分泌[1]。

[References]

[1]. Hu J, et al. Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents. Eur J Med Chem. 2013 Jun;64:292-301.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
579.8±53.0 °C at 760 mmHg

[ Melting Point ]:
213-215 °C(Solv: acetic acid (64-19-7))

[ Molecular Formula ]:
C₂₀H₁₂N₂OS

[ Molecular Weight ]:
328.39

[ Flash Point ]:
304.5±30.9 °C

[ Exact Mass ]:
328.067047

[ LogP ]:
6.16

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.752