WRW4 TFA

Names

[ Name ]:
WRW4 TFA

[Synonym ]:
NPEC-caged-noradrenalin

Biological Activity

[Description]:

WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].

[References]

[1]. Bae YS, et al. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol. 2004;173(1):607-614.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₁H₆₅N₁₅O₆

[ Molecular Weight ]:
1104.27000

[ Exact Mass ]:
1103.52000

[ PSA ]:
355.46000

[ LogP ]:
8.65230

[ Storage condition ]:
-20℃

WRW4 TFA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds