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ML-098

Names

[ CAS No. ]:
878978-76-8

[ Name ]:
ML-098

[Synonym ]:
1-[2-(2,5-Dimethylphenoxy)ethyl]-1H-indole-3-carboxylic acid
1H-Indole-3-carboxylic acid, 1-[2-(2,5-dimethylphenoxy)ethyl]-
ML-098

Biological Activity

[Description]:

ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Cancer

[Target]

EC50: 77.6 nM (Rab7)[1]


[In Vitro]

Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively)[1].

[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
535.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H19NO3

[ Molecular Weight ]:
309.359

[ Flash Point ]:
277.7±28.7 °C

[ Exact Mass ]:
309.136505

[ PSA ]:
51.46000

[ LogP ]:
4.96

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
2-8℃

Related Compounds