Furan-2-carboxylic acid

Names

[ CAS No. ]:
88-14-2

[ Name ]:
Furan-2-carboxylic acid

[Synonym ]:
2-furanyl-carboxylic acid
pyromucic acid
Furan-2-carboxylic acid
2-FURANCARBONYL CHLORIDE
2-Furoic acid
a-Furoicacid
Kyselina 2-furoova
2- FUROIC ACID
2-FUROIC ACID/FURAN-2-CARBOXYLIC ACID
Furoica
2-FURANCARBOXYLICACID
α-Furoic acid
EINECS 208-422-9
2-Furanoic acid
2-Furancarboxylic acid
MFCD00003228
2-furan-carboxylic acid
a-Furoic Acid

Biological Activity

[Description]:

2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[1]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase

Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase

Research Areas >> Metabolic Disease

[In Vivo]

2-Furoic acid significantly reduces serum cholesterol and serum triglyceride levels[2]. 2-Furoic acid also lowers the liver and small intestine ATP dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase, sn-glycerol 3-phosphate acyl transferase, phosphatidylate phosphohydrolase and heparin induced lipoprotein lipase activities[2]. 2-Furoic acid shows the LD50 of 250 mg/kg i.p. in the acute toxicity studies in mice[2].

[References]

[1]. Wordofa GG, et al. Tolerance and metabolic response of Pseudomonas taiwanensis VLB120 towards biomass hydrolysate-derived inhibitors. Biotechnol Biofuels. 2018 Jul 19;11:199.

[2]. Hall IH, et al. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch Pharm (Weinheim). 1993 Jan;326(1):15-23.

[Related Small Molecules]

Avasimibe | BMS 303141 | LCQ-908 | DGAT-3 | A922500 | Xanthohumol | PF-04620110 | AZD7687 | SB 204990 | MGAT2-IN-1 | DGAT-1 inhibitor 2 | DGAT1-IN-1 | K-604 dihydrochloride | PF-06471553 | YM17E

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
230-232 ºC

[ Melting Point ]:
129-133 ºC

[ Molecular Formula ]:
C₅H₄O₃

[ Molecular Weight ]:
112.084

[ Flash Point ]:
137 ºC

[ Exact Mass ]:
112.016045

[ PSA ]:
50.44000

[ LogP ]:
0.64

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Water Solubility ]:
36 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1763000

CHEMICAL NAME :: 2-Furoic acid

CAS REGISTRY NUMBER :: 88-14-2

BEILSTEIN REFERENCE NO. :: 0110149

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H4-O3

MOLECULAR WEIGHT :: 112.09

WISWESSER LINE NOTATION :: T5OJ BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 1,15,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1977 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 774 (estimated) No. of Female Employees: 10 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
C;Xi

[ Risk Phrases ]:
R34;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S36

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
LV1763000

[ HS Code ]:
29321900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Optimization and Kinetic Studies on Biodiesel Production from Kusum (Schleichera triguga) Oil Using Response Surface Methodology.

J. Oleo Sci. 64 , 987-97, (2015)

In the present study, the low-cost non-edible kusum (Schleichera triguga) oil with a substantial amount of free fatty acid (FFA) was utilized for biodiesel synthesis. In pretreatment step, FFA was red...

High tolerance and physiological mechanism of Zymomonas mobilis to phenolic inhibitors in ethanol fermentation of corncob residue.

Biotechnol. Bioeng. 112 , 1770-82, (2015)

Corncob residue as the lignocellulosic biomass accumulated phenolic compounds generated from xylitol production industry. For utilization of this biomass, Zymomonas mobilis ZM4 was tested as the ethan...