m-PEG8-O-alkyne

Names

[ CAS No. ]:
880081-81-2

[ Name ]:
m-PEG8-O-alkyne

[Synonym ]:
mPEG8-CH2C≡CH

Biological Activity

[Description]:

m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₈O₉

[ Molecular Weight ]:
422.51000

[ Exact Mass ]:
422.25200

[ PSA ]:
83.07000

[ LogP ]:
0.39880

m-PEG8-O-alkyne

Names

Biological Activity

Chemical & Physical Properties

Related Compounds