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HDS 029

Names

[ CAS No. ]:
881001-19-0

[ Name ]:
HDS 029

[Synonym ]:
HMS3229E05
EGFR/ErbB-2/ErbB-4 Inhibitor
IN1346
HDS 029

Biological Activity

[Description]:

EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

ErbB2:1.1 nM (IC50)

ErbB1:0.3 nM (IC50)

ErbB4:0.5 nM (IC50)

EGFR:2.5 nM (IC50)

HER:24 nM (IC50)


[References]

[1]. Klutchko SR, et al. Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem. 2006 Feb 23;49(4):1475-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H11ClFN5O

[ Molecular Weight ]:
355.75400

[ Exact Mass ]:
355.06400

[ PSA ]:
83.29000

[ LogP ]:
4.24520

Related Compounds