Ethylhexyl triazone

Names

[ Name ]:
Ethylhexyl triazone

[Synonym ]:
Tris(2-ethylhexyl) 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
Uvinul T150
UVT-150
Octyl triazone
T6N CN ENJ BMR DVO1Y4&2& DMR DVO1Y4&2& FMR DVO1Y4&2
2,4,6-Trianilino(p-carbo-2-ethylhexyl-1-oxy)-1,3,5-triazine
Ethylhexyl triazone
Uvinul T 150
Benzoic acid, 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tris-, tris(2-ethylhexyl) ester

Biological Activity

[Description]:

Ethylhexyl triazone is an approved ultraviolet-B (UV-B) chemical filter for commercial sunscreens.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vitro]

One property of Ethylhexyl triazone (EHT) is its large molecular weight (823.07 g/mol); such filters are unlikely to penetrate the skin, thereby reducing effects associated with such skin penetration. It displays a broad absorption profile across the UV-B region, with a maximum absorption at ~311 and ~313 nm for Ethylhexyl triazone-dioxane and Ethylhexyl triazone-methanol, respectively[1].

[References]

[1]. Pinto-Bazurco Mendieta MA, et al. Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment ofprostate cancer to reduce risks of cardiovascular diseases. J Med Chem. 2013 Aug 8;56(15):6101-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
869.5±75.0 °C at 760 mmHg

[ Melting Point ]:
128°

[ Molecular Formula ]:
C₄₈H₆₆N₆O₆

[ Molecular Weight ]:
823.074

[ Flash Point ]:
479.6±37.1 °C

[ Exact Mass ]:
822.504395

[ PSA ]:
153.66000

[ LogP ]:
15.53

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.576

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Statements ]:
H413

[ Risk Phrases ]:
53

[ Safety Phrases ]:
61

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

In vitro evaluation of Sun Protection Factor and stability of commercial sunscreens using mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 13-9, (2015)

Sunlight exposure causes several types of injury to humans, especially on the skin; among the most common harmful effects due to ultraviolet (UV) exposure are erythema, pigmentation and lesions in DNA...

Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.

Chemosphere 62(6) , 915-25, (2006)

Many substances related to human activities end up in wastewater and accumulate in sewage sludge. The present study focuses on the analysis of widely used UV filters 3-(4-methylbenzylidene) camphor (4...

Quantification of sunscreen ethylhexyl triazone in topical skin-care products by normal-phase TLC/densitometry.

ScientificWorldJournal 2012 , 807516, (2012)

Ethylhexyl triazone (ET) was separated from other sunscreens such as avobenzone, octocrylene, octyl methoxycinnamate, and diethylamino hydroxybenzoyl hexyl benzoate and from parabens by normal-phase H...